TP53 reference sequences used in the database
Reference sequences for TP53 gene and p53 protein can be found here.
Where do I find the description of the annotations used in the database?
All annotations are described in details in the User's manual.
Mutations screened from RNA
All mutations are annotated in the database at the genomic level.
For mutations identified from RNA screening, annotations may not be accurate.
For example, a mutation described as a deletion of exon 5 at RNA level might in
fact be a point mutation located in a splice site at the genomic level
(inducing skiping of an exon). It is of note that this concerns only a small
fraction of the data included in the database. You may exclude studies that
have screened RNA by using the 'Start material' control.
Description of deletions and insertions
The exact location of deletions, insertions and complex variations are often
poorly described in original reports (often reported at the codon but not
genomic level). Annotations for these mutations are thus not precise since we
annotate mutations at the genomic level. For example, if a deletion is described as a
deletion of one nucleotide at codon 158, it is entered in the database as deletion of the
first nucleotide of codon 158 while it may in fact be the second or third nucleotide that is
actualy deleted. This information is thus only reliable at the codon level.