Reports of mutation data often contain errors. This page provides tools to validate and format mutation data. The mutation finder allows the selection of a specific mutation and the retrieval of standard descriptions of this mutation at the genomic and protein levels. It also provides various types of data related to this mutation to help the interpretation of the significance of this mutation in human cancer. TP53 reference sequences and are also available bellow.

Mutation descriptions follow HGVS recommendations.

The reference genomic sequence used for TP53 is NC_000017-9 from GenBank.

Mutation finder

This tool allows the selection of a specific mutation using different input formats and the retrieval of information available in the database for this mutation.

SELECT:

Codon number :  (1 to 393)   and Mutant codon :  (e.g. CAG)

OR

Nucleotide number :     and Mutant base :  (e.g. T)

OR

Mutation (i.e, c.524G>A):

OR

Mutant (i.e, R175H):

---

• TP53 coding sequence
• TP53 gene sequence
• Amino-acid letter codes and properties
• Genetic code

• NNSPLICE splice site analyzer
• Human Splicing Finder
• Align-AGVGD (prediction of functional impact of missense mutations)
• SIFT (prediction of functional impact of missense mutations)
• Scorecons (for scoring residue conservation)