Aim and scope
The IARC TP53 Mutation Database compiles TP53 mutatio data that have been reported in the published literature since 1989. Database updates are preformed once a year and identified by a number.
The current release is R18 (April 2016). The following datasets are available:
- TP53 somatic mutations in sporadic cancers
- TP53 germline mutation in familial cancers
- Common TP53 polymorphisms identified in human populations
- Functional and structural properties of p53 mutant proteins
- TP53 gene status in human cell-lines
- Mouse-models with engineered TP53
- Experimentally-induced mutations
This information is useful to compile tumor-specific mutation patterns and to draw hypotheses on the nature of the molecular events involved in TP53 mutagenesis. It also allows the analysis of genotype/phenotype relationships.
The project consists in:
- Performing regular review of the literature on TP53 mutations;
- Developing electronic formats for the compilation, retrieval and analysis of mutation data;
- Performing research on TP53 mutation patterns and clinical impacts of mutations.
The database includes various annotations on the predicted or experimentally assessed functional impact of mutations, clinicopathologic characteristics of tumors and demographic and life-style information on patients.
The database is meant to be a source of information on TP53 mutations for a broad range of scientists and clinicians who work in different research areas:
- Basic research, to study the structural and functional aspects of the p53 protein
- Molecular pathology of cancer, to understand the clinical significance of mutations identified in cancer patients
- Molecular epidemiology of cancer, to analyze the links between specific exposures and mutation patterns and to make inferences about possible causes of cancer
- Molecular genetics, to analyze genotype/phenotype relationships
Detailed information on data and annotations available is provided in the user guide.