Structures analysis

This page provides a tool to visualize the position of mutations in the 3D structure of the DNA-binding domain of p53 protein. Links to other p53 structures and structural properties of p53 and p53 mutants are also provided.

3D Viewer

View structural motifs of p53 DNA-binding domain in contact with DNA*: color residues (96 to 289) with options bellow (you may select several residues separated by a comma)


Color: Residue number:

* You need to download and install JAVA plug-in to use this tool.


Download structures and tools


Structural impacts of mutations

- M133L/V203A/N239Y/N268D
- M133L/V203A/N239Y/N268D/R273H
- M133L/H168R/V203A/N239Y/N268D
- M133L/V203A/N239Y/R249S/N268D
- M133L/H168R/V203A/N239Y/R249S/N268D
- T123A/M133L/H168R/V203A/N239Y/R249S/N268D

and Joerger AC et al. (2006):

- M133L/V143A/V203A/N239Y/N268D
- M133L/V203A/Y220C/N239Y/N268D
- M133L/V203A/G245S/N239Y/N268D
- M133L/V203A/N239Y/N268D/F270L
- M133L/V203A/N239Y/N268D/R273C
- M133L/V203A/N239Y/N268D/R282W

- Thermodynamic stability data