Reference sequences used to annotate TP53 gene variations

• The Genomic sequence, NC_000017.10 is now used (since R17 version) as default for describing mutations at the genome level. Exon-intron boundaries for the main p53 isoform and polymorphic sites are shown here.
• Coding and protein sequence with residue numbers, amino-acids, highlighted CpG sites and exon-intron boundaries.
• NCBI link to cDNA sequence corresponding to the NM_000546 isoform.

Other links to human sequences

• p53 isoforms
• NCBI EntrezGene
• Gene view at ENSEMBL
• Protein annotations at UniProtKB

Sequences in other species

• Protein sequence alignment
• Structure of p53 C. Elegans Ortholog Cep-1
• Structure of Mouse p53 core domain

Structures

• Download p53 core domain and Rasmol viewer
• p53 core domains bound to DNA
• p53 core domain bound to the ankyrin and SH3 domains of 53BP2
• p53 core domain bound to the Brct Region of 53Bp1
• p53 core domains (2) bound to the Brct Regions (2) of 53Bp1
• p53 tetramerization domain (residues 326-356)
• p53 tetramerization domain (X-ray)
• p53 transactivation domain bound to mdm2