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IARC TP53 Database

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    • Gene variations
    • Somatic mutations
    • Germline mutations
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    • TP53 sequences
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You are here: Home / Database Resources / TP53 sequences
  • Database Resources
  • TP53 sequences
  • Structures analysis
  • Protocols and tools
  • Mutation nomenclatures
  • Data Submision
  • Slide show






















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TP53 sequences

Reference sequences used to annotate TP53 gene variations

  • The Genomic sequence, NC_000017.10 is now used (since R17 version) as default for describing mutations at the genome level. Exon-intron boundaries for the main p53 isoform and polymorphic sites are shown here.
  • Coding and protein sequence with residue numbers, amino-acids, highlighted CpG sites and exon-intron boundaries.
  • NCBI link to cDNA sequence corresponding to the NM_000546 isoform.

Other links to human sequences

  • p53 isoforms
  • NCBI EntrezGene
  • Gene view at ENSEMBL
  • Protein annotations at UniProtKB

Sequences in other species

  • Protein sequence alignment
  • Structure of p53 C. Elegans Ortholog Cep-1
  • Structure of Mouse p53 core domain

Structures

  • Download p53 core domain and Rasmol viewer
  • p53 core domains bound to DNA
  • p53 core domain bound to the ankyrin and SH3 domains of 53BP2
  • p53 core domain bound to the Brct Region of 53Bp1
  • p53 core domains (2) bound to the Brct Regions (2) of 53Bp1
  • p53 tetramerization domain (residues 326-356)
  • p53 tetramerization domain (X-ray)
  • p53 transactivation domain bound to mdm2

  • About
    • Aim & scope
    • Database development
    • Credits
    • Disclaimer
    • Contact us
  • Data
    • Gene variations
    • Somatic mutations
    • Germline mutations
    • Cell-lines
    • Mouse models
    • Exp. induced mutations
    • Download Datasets
    • Selected Statistics
  • User's help
    • User's manual
    • FAQ
    • Contact us
  • Database Resources
    • TP53 sequences
    • Structures analysis
    • Protocols and tools
    • Mutation nomenclatures
    • Data Submision
    • Slide show
  • Refs Corner
    • Publications Highlights
    • Database development papers
    • Database analysis papers
    • Li-Fraumeni syndrome
    • TP53 polymorphisms
  • Links
    • Definitions and functions
    • Other resources
    • p53 research groups
    • Meetings and events
  • LinkedIn
  • RSS
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