Aim and scope

The IARC TP53 Database compiles TP53 mutation data that have been reported in the published literature since 1989 or are available in other public databases. Database releases are identified by a number.

The current and final release is R20 (July 2019). The following data are available:

  • TP53 somatic mutations in sporadic cancers
  • TP53 germline mutations in cancer patients, families with cancers, control populations
  • Common TP53 polymorphisms identified in human populations
  • Functional assessment of p53 mutant proteins
  • TP53 gene status in human cell-lines
  • Mouse-models with engineered TP53
  • Experimentally-induced mutations

This information is useful to compile tumor-specific mutation patterns and to draw hypotheses on the nature of the molecular events involved in TP53 mutagenesis. It also allows the analysis of genotype/phenotype relationships.

The project consists in:

  • Performing regular review of the literature on TP53 mutations;
  • Extracting TP53 data from genetic and genomic databases;
  • Developing standard annotations of TP53 variants;
  • Performing research on TP53 mutation patterns and the origin and clinical impacts of TP53 variants.

The database includes various annotations on the predicted or experimentally assessed functional impact of mutations, clinicopathologic characteristics of tumors and demographic and life-style information on patients.

The database is meant to be a source of information on TP53 mutations for a broad range of scientists and clinicians who work in different research areas:

  • Basic research, to study the structural and functional aspects of the p53 protein
  • Molecular pathology of cancer, to understand the clinical significance of mutations identified in cancer patients
  • Molecular epidemiology of cancer, to analyze the links between specific exposures and mutation patterns and to make inferences about possible causes of cancer
  • Molecular genetics, to analyze genotype/phenotype relationships

Detailed information on data and annotations available is provided in the user guide.